The study conducted at the Institute of Pathology Diagnostics finds its way into virtually all areas of modern patient care : it helps to recognize and accurately assigned to a disease , treatment planning and assessment of treatment success. The fact that the pathology ( and more surgery, internal , gynecology , urology, pediatrics, dermatology. ) With almost all clinical disciplines is in contact and has to cope with a variety of different requirements in this ongoing dialogue , which requires long training and high specialization of here practicing physicians .
The center of the diagnostics is the microscopic examination of cells or tissues that have been removed from a patient (histology and cytology ) . To this end, the material is fixed directly after sampling and embedded in paraffin wax. Through both steps , the tissue is harder and can be cut with precision cutting machines into paper-thin slices of 2 microns , which are mounted on glass slides and stained with appropriate staining methods . The final histological preparation can now be examined under a microscope by a doctor of pathology . Each year, about 200,000 of such preparations are from the staff of our institute prepared and evaluated . ? Over the past few years, the role of pathology has been modified to have that just increasingly taken place by means of inclusion in the management plan of malignant tumors in addition to classical diagnostics, eg by the determination of hormone receptors in breast cancer and the detection of specific genetic changes in solid and hematological tumors.
In such special questions , the information that can be obtained by the sole microscopic observation , to be supplemented by special methods. Such auxiliary methods are especially immunohistochemistry , in which certain structures or molecules in tissues can be visualized by antibodies and, increasingly, modern molecular biological methods.